Since they debuted, injectable GLP-1 medicine like Ozempic have been in excessive demand. Along with treating diabetes and weight problems, these medicines have cardiovascular advantages, and there’s proof they might curb dependancy and probably even shield in opposition to some kinds of cancer, which has solely additional broadened their enchantment. However for individuals who hate needles, these medicines maintain a evident, apparent downside: They require taking a weekly shot.
Now, although, on platforms like Instagram and Fb, adverts for oral knock-off variations of GLP-1 medicine are proliferating. After the brand-name GLP-1 medicine went into scarcity in 2022, a booming business of “compounding” pharmacies and telehealth clinics arose to supply copies of the medicines, as they’re legally permitted to do when shortages exist. However in contrast to the pharma giants that produce the originals, these digital clinics and specialty pharmacies are providing variations of semaglutide and tirzepatide for weight reduction which are taken by mouth. They provide lozenges, tablets, tablets, cheek gels, drops, and dissolving strips, promising to ship the identical energetic substances because the trademark medicines with out the injections.
It’s an interesting prospect—particularly since these medicine are provided at a fraction of the worth of their name-brand counterparts and are sometimes shipped in a single day after a potential affected person fills out a quick online questionnaire. A month’s provide of semaglutide lozenges with vitamin B6 added from the telehealth startup Strut, for instance, prices $149 with out insurance coverage, versus Wegovy’s $1,000-plus price ticket.
“As a pharmacist, I can respect the joy within the rise in oral semaglutide, since it’s a better route than injectables,” says Melinda Lee, a pharmacist who runs the pharmaceutical packaging firm Parcel Well being in addition to a GLP-1 drug availability database. Oral variations additionally don’t must be refrigerated like injectables, which makes them simpler to ship and retailer. However though she understands the keenness, Lee stays skeptical. Whereas taking a drug by mouth may be extra interesting than a needle, on the subject of GLP-1s, the proof that they’re as efficient simply isn’t there but, she says.
In contrast to the brand-name medicine Ozempic, Wegovy, Mounjaro, and Zepbound, compounded variations haven’t been rigorously examined in scientific trials, they usually’re not accredited by the Meals and Drug Administration. And though by regulation they need to comprise the identical energetic ingredient because the drug they mimic, these orally formulated medicines could not work practically in addition to the injectable medicine.
Maria Daniela Hurtado Andrade, an weight problems specialist on the Mayo Clinic in Jacksonville, Florida, says she doesn’t advocate oral compounded GLP-1 medicines to her sufferers. “I don’t think about them, I don’t prescribe them, and I don’t endorse them,” she says.
